Syllabus
Schedule
Reading List
Term Paper
Examinations
Discussion
Directory
Advice
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Reading List
Jan 19 F
Background (from McLoon on embryology of the nervous system)
- Kandel et al., Chapter 52, pp.1165-1170. [also relevant to the next lecture]
Jan 22 M
Background (from Nakagawa on induction)
- Kandel et al., Chapter 52, pp. 1165-1170.
- Ozair et al. (2013) Neural induction and early patterning in vertebrates. WIREs Dev Biol 2: 479-498.
Jan 24 W
Background (from Nakagawa on regionalization)
- Kandel et al., Chapter 52, pp. 1170-1185.
- Kiecker and Lumsden (2012) The role of organizers in patterning the nervous system. Ann Rev Neurosci 35: 347-36.7
Jan 26 F Discussion (from Nakagawa on induction)
- Kiecker & Lumsden (2004) Hedgehog signaling from the ZLI regulates diencephalic regional identity. Nat. Neurosci. 7:1242-1249.
Jan 29 M
Background (from Nakagawa on cell division & lineage)
- Kandel et al., Chapter 53, pp.1187-1192.
- Namba T and Huttner WB (2017) Neural progenitor cells and their role in the development and evolutionary expansion of the neocortex. WIREs Dev Biol 6:e256 1-16.
Jan 31 W
Background (from Nakagawa on cell fate)
- Imayoshi and Kageyama (2014) bHLH factors in self-renewal, multipotency, and fate choices of neural progenitor cells. Neuron 82:9-23.
- Fishell and Heintz (2013) The neuron identity problem: form meets function. Neuron 80: 602-612.
- Kowhi and Doe (2013) Temporal fate specification and neural progenitor competence during development (2013) Nature Reviews in Neuroscience 14: 823-838.
Feb 2 F
Discussion (from Nakagawa on cell division)
- Gao P et al. (2014) Deterministic progenitor behavior and unitary production of neurons in the neocortex. Cell 159: 775-788.
Feb 5 M
Background (from McLoon on neural crest cell migration)
- Kandel et al., Chapter 53, pp. 1192-1200. [also relevant to the next lecture]
- Mayor R, Theveneau E (2013) The neural crest. Development 140:2247-2251.
Feb 7 W
Background (from McLoon on CNS cell migration)
- Kandel et al., Chapter 53, pp. 1192-1200.
- Franco SJ, Muller U (2011) Extracellular matrix functions during neuronal migration and lamination in the mammalian central nervous system. Dev Neurobiol 71:889-900.
Feb 9 F
Discussion (from McLoon on CNS cell migration)
- Ha S, et al. (2017) C-Terminal region truncation of RELN disrupts an interaction with VLDLR, causing abnormal development of the cerebral cortex and hippocampus. J Neurosci 37:960-971.
Feb 12 M
Background (from Lanier on neurite initiation)
- Flynn KC (2014) The cytoskeleton and neurite initiation. Bioarchitecture 3:86–109. [also relevant to the next two lectures].
Feb 14 W
Background (from Lanier on axonal branching)
- Kalil K, Dent EW (2014) Branch management: mechanisms of axon branching in the developing vertebrate CNS. Nat Rev Neurosci 15:7–18
Feb 16 F
Discussion (from Lanier)
- McNeely KC et al. (2017) Mutation of kinesin-6 Kif20b causes defects in cortical neuron polarization and morphogenesis. Neural Development 12: 1-18.
Feb 19 M
Background (from Lanier on axon guidance)
Feb 21 W
Background (from Lanier on axon guidance)
- Averaimo S, Nicol X (2014) Intermingled cAMP, cGMP and calcium spatiotemporal dynamics in developing neuronal circuits. Front Cell Neurosci 8:376.
Feb 23 F
Discussion (from Lanier on axon guidance)
- Kerstein, Patel, Gomez (2017) Calpain-mediated proteolysis of Talin and FAK regulates adhesion dynamics necessary for axon guidance. J Neurosci 37:1568-1580. (P.S. Gomez, the PI for this paper, is a GPN graduate.)
Feb 26 M
Background (from Lanier dendrite growth)
- Jan Y-N, Jan LY (2010) Branching out: mechanismsof dendritic arborization. Nat Rev Neurosci 11:316–328.
- Lewis TL, Polleux F (2012) Neuronal morphogenesis: Golgi outposts, acentrosomal microtubule nucleation, and dendritic branching. Neuron 76:862–864.
Feb 28 W
Background (from Lanier on synapse formation & receptor clustering)
- Kandel et al., Chapter 55, pp.1233-1257
Mar 5 M
Discussion (from Lanier)
nothing has been edited below here
Mar 19
Background (from Lanier on electrical properties)
Mar 21
Background (from McLoon on specificity)
- Kandel et al., Chapter 54, pp.1218-1227.
Mar 23
Background (from McLoon on cell death)
- Kandel et al., Chapter 53, pp. 1200-1208. [also relevant to the next lecture]
Discussion (from McLoon on specificity)
- Hornberg et al. (2016) Hermes regulates axon sorting in the optic tract by post-trancriptional regulation of Neuropilin-1. J Neurosci 36:12697-12706.
Mar 28
Background (from McLoon on trophic factors)
- Dekkers M et al. (2013) Death of developing neurons: New insights and implications for connectivity. J Cell Biol 203:385-393.
Discussion (from McLoon on cell death)
- Chen SK et al. (2013) Apoptosis regulates ipRGC spacing necessary for rods and cones to drive circadian photoentrainment. Neuron 77:503-515.
Mar 30
Background (from Nakagawa on refinement of connections I)
- Kandel et al., Chapter 56, pp.1259-1282.
- Schuldiner and Yaron (2015) Mechanisms of developmental neurite pruning. Cell Mol Life Sci 72: 101-119
Discussion (from McLoon on trophic factors)
- Nakamura et al. (2016) Bcl-xL is essential for the survival and function of differentiated neurons in the cortex that control complex behaviors. J Neurosci 36:5448-5461.
Apr 4
Background (from Nakagawa on refinement of connections II)
- Kandel et al., Chapter 56, pp.1259-1282.
- Assali et al. (2014) Activity dependent mechanisms of visual map formation – from retinal waves to molecular regulators. Seminars in Cell & Developmental Biology 35:136-146.
Discussion (from Nakagawa on refinement of connections I)
- Maor-Nof M et al. (2016) Axonal degeneration is regulated by a transcriptional program that coordinates expression of pro- and anti-degenerative factors. Neuron 92:991-1006.
Apr 6
Background (from Nakagawa on glia I)
Discussion (from Nakagawa on refinement of connections II)
- Bialas AR et al. (2013) TGF-B signaling regulates neuronal C1q expression and developmental synaptic refinement. Nat Neurosci 16:1773-1782.
Apr 11
Background (from Nakagawa on glia II)
Discussion (from Nakagawa on glia I)
- Glasgow SM et al. (2014) Mutual antagonism between Sox10 and NFIA regulates diversification of glial lineages and glioma subtypes. Nat Neurosci 17:1322-1329.
Apr 13
Background (from Nakagawa on disorders)
- Kandel et al., Chapter 62, pp. 1389-1401, Chapter 64, pp. 1425-1440.
Discussion (from Nakagawa on glia II)
- Parkhurst CN et al. (2013) Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor. Cell 155:1596-1609.
Apr 18
Background (from Nakagawa on behavior I)
Discussion (from Nakagawa on disorders)
- Durak O, et al. (2016) Chd8 mediates cortical neurogenesis via transcriptional regulation of cell cycle and Wnt signaling. Nat Neurosci 19: 1477-1488.
Apr 20
Background (from Nakagawa on behavior II)
Discussion (from Nakagawa on behavior I)
- Yang CF et al. (2013) Sexually dimorphic neurons in the ventromedial hypothalamus govern mating in both sexes and aggression in males. Cell 153:896-909.
Apr 25
Background (from McLoon on adult neurogenesis)
- Kandel et al., Chapter 57, pp.1296-1303.
Discussion (from Nakagawa on behavior II)
- Lee HHC et al. (2017) Genetic Otx2 mis-localization delays critical period plasticity across brain regions. Molecular Psch. 00:1-9.
May 2
Background (from McLoon on reaction to injury & regeneration)
- Kandel et al., Chapter 57, pp. 1284-1295.
- Ferguson, Son (2011) Extrinsic and intrinsic determinants of nerve regeneration. J Tissue Eng 2:1-12.
Discussion (from McLoon on adult gliogenesis)
May 4
Discussion (from McLoon on reaction to injury & regeneration)
- Anderson, et al. (2016) Astrocyte scar formation aids central nervous system axon regeneration. Nature 532:195-200.
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