Nsc8211: Developmental Neurobiology

Syllabus
Announcements
Schedule
Reading List
Term Paper
Examinations
Discussion
Directory
Advice

Reading List

 

Jan 17
Background (from McLoon on embryology of the nervous system)

  • Kandel et al., Chapter 52, pp.1165-1170. [also relevant to the next lecture]

Jan 19
Background (from Nakagawa on induction)

  • Kandel et al., Chapter 52, pp. 1165-1170.
  • Ozair et al. (2013) Neural induction and early patterning in vertebrates. WIREs Dev Biol 2: 479-498.

Jan 24
Background (from Nakagawa on regionalization)

  • Kandel et al., Chapter 52, pp. 1170-1185.
  • Kiecker and Lumsden (2012) The role of organizers in patterning the nervous system. Ann Rev Neurosci 35: 347-36.7

Discussion (from Nakagawa on induction)

  • Garriock RJ et al. (2015) Lineage tracing of neuromesodermal progenitors reveals novel Wnt-dependent roles in trunk progenitor cell maintenance and differentiation. Development 142: 1628-1638.

Jan 26
Background (from Nakagawa on cell fate)

  • Imayoshi and Kageyama (2014) bHLH factors in self-renewal, multipotency, and fate choices of neural progenitor cells. Neuron 82:9-23.
  • Fishell and Heintz (2013) The neuron identity problem: form meets function. Neuron 80: 602-612.
  • Kowhi and Doe (2013) Temporal fate specification and neural progenitor competence during development (2013) Nature Reviews in Neuroscience 14: 823-838.

Discussion (from Nakagawa on regionalization)

  • Yu T et at. (2013) Deregulated FGF and homeotic gene expression underlies cerebellar vermis hypoplasia in CHARGE syndrome. eLIFE 2:e01305: 1-15.

Jan 31
Background (from Nakagawa on cell division & lineage)

  • Kandel et al., Chapter 53, pp.1187-1192.
  • Namba T and Huttner WB (2017) Neural progenitor cells and their role in the development and evolutionary expansion of the neocortex. WIREs Dev Biol 6:e256 1-16.

Discussion (from Nakagawa on cell fate)

  • Wu F et al. (2015) Two transcription factors, Pou4f2 and Isl1, are sufficient to specify the retinal ganglion cell fate. PNAS 112: E1559-68.

Feb 2
Background (from McLoon on neural crest cell migration)

  • Kandel et al., Chapter 53, pp. 1192-1200. [also relevant to the next lecture]
  • Mayor R, Theveneau E (2013) The neural crest. Development 140:2247-2251.

Discussion (from Nakagawa on cell division & lineage)

  • Wang L et al. (2016) Hedgehog signaling promotes basal progenitor expansion and the growth and folding of the neocortex. Nat Neurosci 19: 888-896.

Feb 7
Background (from McLoon on CNS cell migration)

  • Kandel et al., Chapter 53, pp. 1192-1200.
  • Franco SJ, Muller U (2011) Extracellular matrix functions during neuronal migration and lamination in the mammalian central nervous system. Dev Neurobiol 71:889-900.

Discussion (from McLoon on neural crest cell migration)

Feb 9
Background (from Lanier on neurite initiation)

  • Flynn KC (2014) The cytoskeleton and neurite initiation. Bioarchitecture 3:86–109. [also relevant to the next two lectures].

Discussion (from McLoon on CNS cell migration)

  • Murillo B, et al. (2015) Zic2 controls the migration of specific neuronal populations in the developing forebrain. J Neurosci 35:11266-11280.

Feb 14
Background (from Lanier on axonal branching)

  • Kalil K, Dent EW (2014) Branch management: mechanisms of axon branching in the developing vertebrate CNS. Nat Rev Neurosci 15:7–18

Discussion (from Lanier on neurite initiation)

  • Sahasrabudhe A et al. (2016) Formin 2 regulates the stabilization of filopodial tip adhesions in growth cones and affects neuronal outgrowth and pathfinding in vivo. Devbelopment 143: 449-460.

Feb 16
Background (from Lanier on axon guidance I)

Discussion (from Lanier on axonal branching)

  • Gupton, Gertler (2010) Integrin signaling switches the cytoskeletal and exocytic machinery that drives neuritogenesis. Dev Cell 18:725-736.  [when reading this article, think about how the principles that govern neurite initition may apply to axon branching]

Feb 21
Background (from Lanier on axon guidance II)

  • Averaimo S, Nicol X (2014) Intermingled cAMP, cGMP and calcium spatiotemporal dynamics in developing neuronal circuits. Front Cell Neurosci 8:376.

Discussion (from Lanier on axon guidance I)

  • Fusco L et al. (2016) Computer vision profiling of neurite outgrowth dynamics reveals spatiotemporal modularity of Rho GTPase signaling. J Cell Biol 212:91-111.

Feb 23
Background (from Lanier dendrite growth)

  • Jan Y-N, Jan LY (2010) Branching out: mechanismsof dendritic arborization. Nat Rev Neurosci 11:316–328.
  • Lewis TL, Polleux F (2012) Neuronal morphogenesis: Golgi outposts, acentrosomal microtubule nucleation, and dendritic branching. Neuron 76:862–864.

Discussion (from Lanier on axon guidance II)

  • Kerstein, Patel, Gomez (2017) Calpain-mediated proteolysis of Talin and FAK regulates adhesion dynamics necessary for axon guidance. J Neurosci 37:1568-1580. (P.S. Gomez, the PI for this paper, is a GPN graduate.)

Feb 28
Background (from Lanier on synapse formation)

Discussion (from Lanier on dendrite growth)

  • Sears JC and Broihier HT (2016) FoxO regulates microtubule dynamics and polarity to promote dendrite branching in Drosophila sensory neurons. Dev Biol 418:40-54.

Mar 2
Discussion (from Lanier on synapse formation)

Mar 21
Background (from McLoon on specificity)

  • Kandel et al., Chapter 54, pp.1218-1227.

Mar 23
Background (from McLoon on cell death)

  • Kandel et al., Chapter 53, pp. 1200-1208. [also relevant to the next lecture]

Discussion (from McLoon on specificity)

  • Hornberg et al. (2016) Hermes regulates axon sorting in the optic tract by post-trancriptional regulation of Neuropilin-1. J Neurosci 36:12697-12706.

Mar 28
Background (from McLoon on trophic factors)

  • Dekkers M et al. (2013) Death of developing neurons: New insights and implications for connectivity. J Cell Biol 203:385-393.

Discussion (from McLoon on cell death)

  • Chen SK et al. (2013) Apoptosis regulates ipRGC spacing necessary for rods and cones to drive circadian photoentrainment. Neuron 77:503-515.

Mar 30
Background (from Nakagawa on refinement of connections I)

  • Kandel et al., Chapter 56, pp.1259-1282.
  • Schuldiner and Yaron (2015) Mechanisms of developmental neurite pruning. Cell Mol Life Sci 72: 101-119

Discussion (from McLoon on trophic factors)

  • Nakamura et al. (2016) Bcl-xL is essential for the survival and function of differentiated neurons in the cortex that control complex behaviors. J Neurosci 36:5448-5461.

Apr 4
Background (from Nakagawa on refinement of connections II)

  • Kandel et al., Chapter 56, pp.1259-1282.
  • Assali et al. (2014) Activity dependent mechanisms of visual map formation – from retinal waves to molecular regulators. Seminars in Cell & Developmental Biology 35:136-146.

Discussion (from Nakagawa on refinement of connections I)

  • Maor-Nof M et al. (2016) Axonal degeneration is regulated by a transcriptional program that coordinates expression of pro- and anti-degenerative factors. Neuron 92:991-1006.

Apr 6
Background (from Nakagawa on glia I)

Discussion (from Nakagawa on refinement of connections II)

  • Bialas AR et al. (2013) TGF-B signaling regulates neuronal C1q expression and developmental synaptic refinement. Nat Neurosci 16:1773-1782.

Apr 11
Background (from Nakagawa on glia II)

Discussion (from Nakagawa on glia I)

  • Glasgow SM et al. (2014) Mutual antagonism between Sox10 and NFIA regulates diversification of glial lineages and glioma subtypes. Nat Neurosci 17:1322-1329.

Apr 13
Background (from Nakagawa on disorders)

  • Kandel et al., Chapter 62, pp. 1389-1401, Chapter 64, pp. 1425-1440.

Discussion (from Nakagawa on glia II)

  • Parkhurst CN et al. (2013) Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor. Cell 155:1596-1609.

Apr 18
Background (from Nakagawa on behavior I)

Discussion (from Nakagawa on disorders)

  • Durak O, et al. (2016) Chd8 mediates cortical neurogenesis via transcriptional regulation of cell cycle and Wnt signaling. Nat Neurosci 19: 1477-1488.

Apr 20
Background (from Nakagawa on behavior II)

Discussion (from Nakagawa on behavior I)

  • Yang CF et al. (2013) Sexually dimorphic neurons in the ventromedial hypothalamus govern mating in both sexes and aggression in males. Cell 153:896-909.

Apr 25
Background (from McLoon on adult neurogenesis)

  • Kandel et al., Chapter 57, pp.1296-1303.

Discussion (from Nakagawa on behavior II)

  • Lee HHC et al. (2017) Genetic Otx2 mis-localization delays critical period plasticity across brain regions. Molecular Psch. 00:1-9.

May 2
Background (from McLoon on reaction to injury & regeneration)

  • Kandel et al., Chapter 57, pp. 1284-1295.
  • Ferguson, Son (2011) Extrinsic and intrinsic determinants of nerve regeneration. J Tissue Eng 2:1-12.

Discussion (from McLoon on adult gliogenesis)

May 4
Discussion (from McLoon on reaction to injury & regeneration)

  • Anderson, et al. (2016) Astrocyte scar formation aids central nervous system axon regeneration. Nature 532:195-200.